Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Tahilani, Praveen
- Formulation and Charaterization of Antifungal Drug Microemulsion Hydrogel for Topical Drug Delivery
Abstract Views :73 |
PDF Views:0
Authors
Affiliations
1 Assistant Professor, Department of Pharmaceutical, SIRTS Pharmacy, Bhopal (M.P.), IN
1 Assistant Professor, Department of Pharmaceutical, SIRTS Pharmacy, Bhopal (M.P.), IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 2 (2022), Pagination: 101-108Abstract
Clotrimazole is a broad-spectrum antimycotic drug, Candida albicans as well as other fungal infections are typically treated with this drug. “Clinical clotrimazole seems to be a topical therapy treating tineapedis (athlete's foot), vulvovaginal candidiasis, and oropharyngeal candidiasis.” That is a synthetic azole antimycotic. It inhibits fungal growth by decreasing the production of ergosterol. Clotrimazole has become a medication of interest for a variety of illnesses, including sickle cell anaemia, malaria, and some cancers, in addition to its antimycotic properties. It's been mixed with other molecules as well, to create clotrimazole compounds with enhanced pharmacological effectiveness, including such metals. Numerous novel pharmaceutical formulations enabling variable releases are also being developed. Clotrimazole is a well-tolerated, little-adverse drug, however certain immune compromised individuals are developing treatment resistance. Clotrimazole's pharmaceutical chemistry, use, and pharmacology are discussed in this study.Keywords
Antifungal Property, Microemulsion HydrogelReferences
- Carbone. C., Teixeira. M. D. C., Sousa. M. D. C., Martins-Gomes. C., Silva. A. M., Souto. E. M. B., and Musumeci. T., “Clotrimazole-loaded Mediterranean essential oils NLC: a synergic treatment of Candida skin infections. Pharmaceutics”, 2019, 11(5), 231.
- Blokhina. S., Sharapova. A., Ol’khovich. M., and Perlovich. G. “Experimental solubility of clotrimazole and some thermodynamic aspects of dissolution in different solvents, 2019,682.
- Mehta D. P., Rathod H. J., and Shah D.P. “Design, development and characterization of microemulsion based hydrogel of clotrimazole for topical delivery system”,2019,1-10.
- Carbone C., Fuochi V., Zielińska A., Musumeci L., Souto E.B., Bonaccorso A., Puglia C., Petronio Petronio, P.M. Furneri, “Dual-drugs delivery in Solid Lipid Nanoparticles for the treatment of Candida albicans mycosis, Colloids and Surfaces B: Biointerfaces”, 2019,10,70.
- Victor Midlej, Felipe Rubim, Wilmer Villarreal, Érica S. Martins-Duarte, Maribel Navarro, Wanderley de Souza, Marlene Benchimol, Zinc-clotrimazole complexes are effective against Trichomonas vaginalis, Parasitology, 2019, 1-11.
- Vainstein, Mário Lettieri Teixeira, Ricardo José Alves, Alexandre Meneghello Fuentefria, “Chloroacetamide derivatives as a promising topical treatment for fungal skin infections, Mycologia”, 2019, 1-12.
- Chaiyakarn Pornpitchanarong, Kanokwan Singpanna, Theerasak Rojanarata, Praneet Opanasopit, Tanasait Ngawhirunpat, Prasopchai Patrojanasophon, Catechol-Bearing Hyaluronic Acid Coated Polyvinyl Pyrrolidone/ Hydroxyl Propyl-β- Cyclodextrin/Clotrimazole Nanofibers for Oral Candidiasis Treatment, Key Engineering Materials, 2019, 163-168.
- Ali A., Muhammad, I. N., Hasan, S. F., and Mushtaque, M. “Development and Pharmaceutical Evaluation of Clotrimazole Loaded Topical Hydrogel Formulation”, 2018, 675-81.
- Atefeh Zare, Zeinab Moshfeghy, Mohammad M. Zarshenas, Bahia Namavar jahromi, Marzieh Akbarzadeh, Mehrab Sayadi, Quercus Brantii Lindl. “Vaginal Cream versus Placebo on Bacterial Vaginosis: a Randomized Clinical Trial, Journal of Herbal Medicine”, 2018, 11, 003.
- Amanpreet Kaur, Kiran Jyoti, Ashish Baldi, Upendra Kumar Jain, Ramesh Chandra, Jitender Madan, “Self-assembled nanomicelles of amphiphilic clotrimazole glycyl-glycine analogue augmented drug delivery, apoptosis and restrained melanoma tumour progression, Materials Science and Engineering”, 2018.03.030, 89, 75-86.
- Daniel Escorsim Machado, Jamila Alessandra Perini, Erika Menezes de Mendonça, Jessica Ristow Branco, Karina Cristina Rodrigues-Baptista, Jessica Alessandra-Perini, Jair Machado Espíndola-Netto, Thiago Alves dos Santos, Wagner Santos Coelho, Luiz Eurico Nasciutti, Mauro Sola-Penna, Patricia Zancan, Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis, Molecular and Cellular Endocrinology, 10.1016/j.mce.2018.04.005, 476, 17-26.
- Blanca Regina de la Paz Cota, Pedro Pablo Cepero Vega, Juan José Matus Navarrete, Gerardo Efrain Aguado Mulgado, José Juan Narváez Huerta, Enrique Lamadrid Bautista, Epifanio Fiscal Chauteco, “Efficacy and safety of eberconazole 1% otic solution compared to clotrimazole 1% solution in patients with otomycosis, American Journal of Otolaryngology”, 2018, 017, 307-312.
- Thalita Gagini, Legna Colina-Vegas, Wilmer Villarreal, Luana Pereira Borba- Santos, Caroline de Souza Pereira, Alzir Azevedo Batista, Marcos Kneip Fleury, Wanderley de Souza, Sonia Rozental, Luiz Antônio S. Costa, Maribel Navarro, “Metal–azole fungistatic drug complexes as anti- Sporothrix spp. agents, New Journal of Chemistry”, 2018, 13641-13650.
- Mafalda Cavalheiro, Catarina Costa, Ana Silva-Dias, Isabel M. Miranda, Can Wang, Pedro Pais, Sandra N. Pinto, Dalila Mil-Homens, Michiyo Sato- Okamoto, Azusa Takahashi-Nakaguchi, Raquel M. Silva, Nuno P. Mira, Arsénio M. Fialho, Hiroji Chibana, Acácio G. Rodrigues, Geraldine Butler, Miguel C. Teixeira, “A Transcriptomics Approach To Unveiling the Mechanisms of In Vitro Evolution towards Fluconazole Resistance of a Candida glabrata Clinical Isolate, Antimicrobial Agents and chemotherapy”,2018,10.
- Crowley, P. D., and Gallagher, H. C. “Clotrimazole as a pharmaceutical: past, present and future, Journal of applied microbiology”, 2014 611-617.
- Valerio, C., Perillo, T., Brescia, L. and Russo, F. “Antifungal Agents in Current Pediatric Practice”, 2013, 278-287.
- Porsbring, T., Blanck, H., Tjellström, H. and Backhaus, T. “The pharmaceutical clotrimazole affects marine microalgal communities at picomolar concentrations”, 2009.
- Martins S., Sarmento B., Souto E.B., Ferreira D.C. – “Insulin-loaded alginate microspheres for oral delivery, Effect of polysaccharide reinforcement on physicochemical properties and release profile. - Carbohyd. Polym.”, 69, 725-731, 2007.
- Hicks, R.G. “What's new in stable radical chemistry? Org Biomol Chem 5”, 2007, 1321-1338.
- Sobel, J.D.“Vulvovaginal candidosis”, 2007, 1961-1971.
- Sweetman, S.C., “Martindale: the complete drug reference ed. Sweetman, S.C. p.764 London: Pharmaceutical Press”, 2007.
- Kalb, R. and Grossman, M. “Contact dermatitis to clotrimazole. Cutis 36, 240-242.Lorand, T. and Kocsis, B. Recent advances in antifungal agents. Mini-Rev Med Chem 7”, 2007, 900-91.
- White, T.C., Holleman, S., Dy, F., Mirels, L.F. and Stevens, D.A.“Resistance mechanisms in clinical isolates of Candida albicans. Antimicrob Agents Chemother”, 2002,1704- 1713.
- Eliel, E.L., Wilen, S.H. and Mander, L.N. “Stereochemistry of organic compounds eds”, 1994.
- Hitchcock, C.A., Dickinson, K., Brown, S., Evans, E. and Adams, D. “Interaction of azole antifungal antibiotics with cytochrome P-450-dependent 14 alpha-sterol demethylase purified from Candida”, 1990, 475-480.
- Eaton, D. and Wilson, K. “Reaction of imidazole and hydroquinone with oxymyoglobin”, 1979, 195-203.
- Eaton, D.R. and Wilkins, R.G. “Reduction by dithionite ion of adducts of metmyoglobin with imidazole, pyridine, and derivatives”, 1978, 908-915.
- Sawyer, P. R., Brogden, R. N., Pinder, K. M., Speight, T. M., and Avery, G. S. “Clotrimazole: a review of its antifungal activity and therapeutic efficacy. Drugs”, 1975, 424-447.
- Eaton, D.R. and Wilkins, R.G. (1978) Reduction by dithionite ion of adducts of metmyoglobin with imidazole, pyridine, and derivatives. J Biol Chem 253, 908–9.
- The Era of Artificial Intelligence in Pharmaceutical Industries - A Review
Abstract Views :69 |
PDF Views:0
Authors
Affiliations
1 Sagar Institute of Research and Technology - Pharmacy, Bhopal, MP., IN
2 School of Pharmaceutical Science, SAGE University, Indore, M.P., IN
1 Sagar Institute of Research and Technology - Pharmacy, Bhopal, MP., IN
2 School of Pharmaceutical Science, SAGE University, Indore, M.P., IN
Source
Research Journal of Science and Technology, Vol 14, No 3 (2022), Pagination: 183-187Abstract
As a growing sector, the Era of Artificial Intelligence, Machine Learning and Data Science in the Pharmaceutical Industry contributes in the drug discovery process, giving emphasis on how new technologies have improved effectiveness. As in the current scenario artificial intelligence including machine learning may be considered the future for a wide range of disciplines and industries specially the pharmaceutical industry. As we know today pharmaceutical industries producing a single approved drug cost the company millions with many years of rigorous testing prior to its approval, reducing costs and time is of high interest. The involvement of Artificial Intelligence will be useful to the pharmaceutical industry and also be of interest to anyone doing research in chemical biology, computational chemistry, medicinal chemistry and bioinformatics.Keywords
Artificial Intelligence, Pharmaceutical, Machine learning, Research, Chemistry.References
- Mak KK, Pichika MR. Artificial intelligence in drug development: Present status and future prospects. Drug Discov Today. 2019;24(3):773-80.
- Hassanzadeh P, Atyabi F, Dinarvand R. The significance of artificial intelligence in drug delivery system design. Adv Drug Deliv Rev. 2019;151:169-90.
- Russel S, Dewey D, Tegmark M. Research priorities for robust and beneficial artificial intelligence. AI Mag. 2015;36(4):105-14.
- Duch W, Setiono R, Zurada JM. Computational intelligence methods for rulebased data understanding. Proc IEEE. 2004;92(5):771-805.
- Dasta JF. Application of artificial intelligence to pharmacy and medicine. Hosp Pharm. 1992;27(4):319-22.
- Jiang F, Jiang Y, Zhi H. Artificial intelligence in healthcare: Past, present and future. Stroke Vasc Neurol. 2017;2(4):230-43.
- Gobburu JV, Chen EP. Artificial neural networks as a novel approach to integrated pharmacokinetic-pharmacodynamic analysis. J Pharm Sci. 1996;85(5):505-10.
- Sakiyama Y. The use of machine learning and nonlinear statistical tools for ADME prediction. Expert Opin Drug Metab Toxicol. 2009;5(2):149-69.
- Ramesh A. Artificial intelligence in medicine. Ann. R. Coll. Surg. Engl. 2004; 86:334–338.
- Miles J., Walker A. The potential application of artificial intelligence in transport. IEE Proc.-Intell. Transport Syst. 2006;153:183–198
- Yang Y., Siau K. MWAIS; 2018. A Qualitative Research on Marketing and Sales in the Artificial Intelligence Age.
- Wirtz B.W. Artificial intelligence and the public sector—applications and challenges. Int. J. Public Adm. 2019;42:596–615.
- Smith R.G., Farquhar A. The road ahead for knowledge management: an AI perspective. AI Mag. 2000;21 17–17.
- Lamberti M.J. A study on the application and use of artificial intelligence to support drug development. Clin. Ther. 2019;41:1414–1426.
- Beneke F., Mackenrodt M.-O. Artificial intelligence and collusion. IIC Int. Rev. Intellectual Property Competition Law. 2019;50:109–134.
- Steels L., Brooks R. Routledge; 2018. The Artificial Life Route to Artificial Intelligence: Building Embodied, Situated Agents.
- Bielecki A., Bielecki A. Foundations of artificial neural networks. In: Kacprzyk Janusz., editor. Models of Neurons and Perceptrons: Selected Problems and Challenges. Springer International Publishing; 2019. pp. 15–28. Polish academy of sciences, Warsaw, Poland.
- Kalyane D. Artificial intelligence in the pharmaceutical sector: current scene and future prospect. In: Tekade Rakesh K., editor. The Future of Pharmaceutical Product Development and Research. Elsevier; 2020. pp. 73–107.
- Russell S, Dewey D, Tegmark M. Research priorities for robust and beneficial artificial intelligence. Ai Magazine. 2015 Dec 31;36(4):105-14.
- Lakshmi Teja T, Keerthi P, Debarshi Datta NB. Recent trends in the usage of robotics in pharmacy.
- Yussupova N, Kovács G, Boyko M, Bogdanova D. Models and methods for quality management based on artificial intelligence applications. Acta Polytechnica Hungarica. 2016 Mar; 13(3):45-60 22.
- Brady M. Artificial intelligence and robotics. In Robotics and Artificial Intelligence 1984 (pp. 47-63). Springer, Berlin, Heidelberg.
- Guo M. A prototype intelligent hybrid system for hard gelatin capsule formulation development. Pharm. Technol. 2002;6:44–52. 24. Mehta C.H. Computational modeling for formulation design. Drug Discovery Today. 2019;24:781–788.
- Zhao C. Toward intelligent decision support for pharmaceutical product development. J. Pharm. Innovation. 2006;1:23–35.
- Rantanen J., Khinast J. The future of pharmaceutical manufacturing sciences. J. Pharm. Sci. 2015;104:3612–3638.
- Ketterhagen W.R. Process modeling in the pharmaceutical industry using the discrete element method. J. Pharm. Sci. 2009;98:442–470.
- Chen W. Mathematical model-based accelerated development of extended-release metformin hydrochloride tablet formulation. AAPS PharmSciTech. 2016;17:1007–1013.
- Meziane F. Intelligent systems in manufacturing: current developments and future prospects. Integr. Manuf. Syst. 2000;11:218–238.
- Steiner S. Organic synthesis in a modular robotic system driven by a chemical programming language. Science. 2019;363:eaav2211.
- Faure A. Process control and scale-up of pharmaceutical wet granulation processes: a review. Eur. J. Pharm. Biopharm. 2001;52:269–277.
- Landin M. Artificial intelligence tools for scaling up of high shear wet granulation process. J. Pharm. Sci. 2017;106:273–277.
- Das M.K., Chakraborty T. ANN in pharmaceutical product and process development. In: Puri Munish., editor. Artificial Neural Network for Drug Design, Delivery and Disposition. Elsevier; 2016. pp. 277–293.
- Gams M. Integrating artificial and human intelligence into tablet production process. AAPS PharmSciTech. 2014;15:1447–1453.
- Kraft, D.L. System and methods for the production of personalized drug products. US20120041778A1.
- Aksu B. A quality by design approach using artificial intelligence techniques to control the critical quality attributes of ramipril tablets manufactured by wet granulation. Pharm. Dev. Technol. 2013;18:236–245.
- 96. Goh W.Y. Application of a recurrent neural network to prediction of drug dissolution profiles. Neural Comput. Appl. 2002;10:311–317.
- Drăgoi E.N. On the use of artificial neural networks to monitor a pharmaceutical freeze-drying process. Drying Technol. 2013;31:72–81. 38. Reklaitis R. PharmaHub; 2008. Towards Intelligent Decision Support for Pharmaceutical Product Development.
- Wang X. 2009 International Conference on Computational Intelligence and Software Engineering. IEEE; 2009. Intelligent quality management using knowledge discovery in databases; pp. 1–4.
- Hay M. Clinical development success rates for investigational drugs. Nat. Biotechnol. 2014;32:40–51.